Key result
HnRNP L binds in a sequence-specific manner to a 119-nucleotide RNA sequence element from the HSV-TK gene, enabling intron-independent gene expression and RNA accumulation in the cytoplasm.
Identification of a cis-acting RNA sequence element that binds hnRNP L to enable intron-independent gene expression.
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May inform intronless vector design for gene therapy; leaves open translation to mammalian systems and clinical use.
Liu et al. (1995) studied this question. 119-nucleotide sequence element from HSV-TK gene was evaluated on Cytoplasmic accumulation of globin RNA in the absence of splicing. HnRNP L binds in a sequence-specific manner to a 119-nucleotide RNA sequence element from the HSV-TK gene, enabling intron-independent gene expression and RNA accumulation in the cytoplasm.
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