Key result
hnRNP K promotes chicken beta-tropomyosin exon 6A splicing via the wild-type S4 enhancer sequence.
Population
Chicken beta-tropomyosin pre-mRNA splicing model (in vivo and in vitro)
Comparison
Different enhancer sequences and recombinant… vs Weak enhancer sequences; nuclear extracts…
Design
Preclinical
Authors
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Chicken data offer no clinical guidance; leaves open hnRNP K's role in human cardiac splicing.
hnRNP K is identified as a key component of the intronic splicing enhancer complex that activates alternative splicing of chicken beta-tropomyosin exon 6A.
Expert-Bezançon et al. (2002) studied this question. Heterogeneous nuclear ribonucleoprotein (hnRNP) K was evaluated on Splicing of the chicken beta-tropomyosin exon 6A. Heterogeneous nuclear ribonucleoprotein (hnRNP) K is a component of an intronic splicing enhancer complex that promotes chicken beta-tropomyosin exon 6A splicing through the wild-type S4 sequence.
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