Key result
Underlying factor VII deficiency in a patient on rivaroxaban confounded the interpretation of prolonged prothrombin time and delayed her surgery.
Case Report (n=1)
Confounding factors like factor VII deficiency should be considered when interpreting prolonged prothrombin time in patients on rivaroxaban.
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Factor VII deficiency may confound PT interpretation in rivaroxaban patients and delay surgery; leaves open need for specific assays in ambiguous cases.
Rivaroxaban is an oral direct Xa inhibitor that can lead to prolongation of prothrombin time and activated partial thromboplastin time. However, these basic coagulation tests are not specific for the anticoagulant effect of rivaroxaban and other confounding factors should be considered while interpreting the test results. We report a case of a patient on rivaroxaban, where underlying factor VII deficiency led to confusion in the interpretation of prothrombin time results and delayed her surgery.
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Sagheer et al. (2017) conducted a case report in Prolonged prothrombin time on rivaroxaban (n=1). Rivaroxaban was evaluated on Prolongation of prothrombin time. Underlying factor VII deficiency in a patient on rivaroxaban confounded the interpretation of prolonged prothrombin time and delayed her surgery.
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