Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 1999European Journal of PharmacologyOpen Access

Contribution of nitric oxide and K+ channel activation to vasorelaxation of isolated rat aorta induced by procaine

View Full Paper
Ask AI
Bookmark
Share

Key result

Procaine induces vasorelaxation in isolated rat aorta through multiple mechanisms, including nitric oxide release and activation of specific K+ channels.

Population

Isolated rat aortic rings

Comparison

Procaine (0.01-3 mM) vs Vehicle/control or various inhibitors

Design

Preclinical

Authors

YHYü HuangCLCW LauFCFranky Leung Chan

Discussion

Loading...

Member takes

Overview

No immediate clinical implications from rat aortic data; leaves open human applicability pending translational studies.

Structured PICO

P
Population
Isolated rat aortic rings
I
Intervention
Procaine (0.01-3 mM)
C
Comparator
Vehicle/control or various inhibitors (L-NNA, L-NAME, methylene blue, tetrapentylammonium, tetraethylammonium)
O
Outcome
Vasorelaxationsurrogate

Procaine induces vasorelaxation in rat aorta through multiple mechanisms, including nitric oxide release, activation of specific K+ channels, and direct inhibition of calcium mobilization.

Cite This Study

Huang et al. (1999) studied this question. Procaine was evaluated on Vasorelaxation. Procaine induces vasorelaxation in isolated rat aorta through multiple mechanisms, including nitric oxide release and activation of specific K+ channels.

synapsesocial.com/papers/6a6e8a95febe604dd7080033https://doi.org/10.1016/s0014-2999(98)00950-9
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium‐derived relaxing factor and nitroprusside compared in noradrenaline‐ and K+‐contracted rabbit and rat aortae.1988 · 33 citations
  2. 2Endothelium‐dependent vasorelaxation independent of nitric oxide and K+ release in isolated renal arteries of rats2001 · 34 citations
  3. 3Attenuation of vasoconstriction by endogenous nitric oxide in rat caudal artery1992 · 58 citations
  4. 4Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of Kv, KATP channels and A2a receptor crosstalk2016 · 12 citations
  5. 5ENDOGENOUS NITRIC OXIDE ATTENUATES β‐ADRENOCEPTOR‐MEDIATED RELAXATION IN RAT AORTA2006 · 13 citations