Key result
Contraction of guinea-pig taenia coli smooth muscle upon carbachol stimulation relies on three calcium sources: the inward spike current, a voltage-dependent channel, and an internal store.
Population
Guinea-pig taenia coli smooth muscle
Design
Preclinical
Authors
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May inform basic models of cholinergic contraction; leaves open translation to human smooth muscle physiology.
This preclinical study identifies three distinct sources of calcium involved in the contraction of guinea-pig taenia coli smooth muscle upon carbachol stimulation.
Brading et al. (1980) studied this question. Carbachol was evaluated on Smooth muscle contraction/tension. Contraction of guinea-pig taenia coli smooth muscle upon carbachol stimulation relies on three calcium sources: the inward spike current, a voltage-dependent channel, and an internal store.
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