Key result
Na-free solutions greatly reduced the contractile responses of guinea-pig taenia coli to carbachol, suggesting intracellular Na is important for maintaining the contractile response.
Why the study?
Does sodium removal affect the contractile response of guinea-pig taenia coli to carbachol?
Population
Guinea-pig taenia coli smooth muscle
Comparison
Na-free solutions and carbachol vs Normal sodium solutions
Design
Preclinical
Authors
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Intracellular Na may modulate smooth muscle contractility; leaves open any cardiac relevance pending targeted studies.
Does sodium removal affect the contractile response of guinea-pig taenia coli to carbachol?
Intracellular sodium appears important for maintaining the contractile response to carbachol in guinea-pig taenia coli smooth muscle, likely involving an intracellular calcium store.
Brading et al. (1980) studied this question. Na-free solutions vs. Normal Na solutions was evaluated on Contractile responses to carbachol. Na-free solutions greatly reduced the contractile responses of guinea-pig taenia coli to carbachol, suggesting intracellular Na is important for maintaining the contractile response.
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