February 1, 1983British Journal of PharmacologyOpen Access

Evidence that ionic channels associated with the muscarinic receptor of smooth muscle may admit calcium

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Population

Guinea-pig intestine smooth muscle

Comparison

Carbachol (2 x 10-10M) in various calcium… vs Baseline or different ionic solutions

Design

Preclinical

Authors

TBT. B. BoltonElectrophysiology KKKenji KitamuraUniversity of Florida

Discussion

Member takes

Implication

Indicates muscarinic calcium influx in intestinal smooth muscle; leaves open applicability to human cardiovascular tissues.

Structured PICO

Population

Guinea-pig intestine smooth muscle

Intervention

Carbachol (2 x 10(-7)-10(-4)M) in various calcium solutions

Comparator

Baseline or different ionic solutions (e.g., Ca-free Na-free solution with EGTA)

Outcome

Membrane potential and conductance changessurrogate

Activation of muscarinic receptors in guinea-pig intestinal smooth muscle opens ionic channels that admit calcium ions, leading to depolarization and tension development.

Cite This Study

Bolton et al. (1983) studied this question.

synapsesocial.com/papers/6a0f0847b7cc3b883f22ff05 https://doi.org/10.1111/j.1476-5381.1983.tb09405.x

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Bookmark

Evidence that ionic channels associated with the muscarinic receptor of smooth muscle may admit calcium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence that ionic channels associated with the muscarinic receptor of smooth muscle may admit calcium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider