Population
Separated longitudinal muscle of the guinea-pig terminal ileum
Comparison
Acetylcholine or carbachol application under… vs Physiological salt solution / baseline conditions
Design
Preclinical
Authors
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Electrogenic Na+ pumping may mediate ACh after-hyperpolarization in ileal smooth muscle; leaves open translation to human physiology or therapeutics.
The application of acetylcholine to guinea-pig ileum smooth muscle stimulates electrogenic sodium pumping, which is responsible for the subsequent after-hyperpolarization.
T. B. Bolton (1973) studied this question.
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