Key result
The estimated incidence of drug-induced long-QT syndrome among patients surviving to reach the hospital in France was approximately 10.9 per million annually (95% CI 7.8-14.8).
Why the study?
What is the incidence and reporting rate of drug-induced long-QT syndrome in a regional population?
Population
861 cases with ICD-10 diagnostic codes for ventricular tachycardia, ventricular fibrillation, and sudden…
Design
Cohort
Follow-up
6 years (1999-2005)
Authors
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Incidence of hospital-surviving drug-induced LQTS ~11 per million yearly; leaves open true burden, underreporting, and genetic susceptibility across agents.
Observational (n=861)
Yes
What is the incidence and reporting rate of drug-induced long-QT syndrome in a regional population?
The incidence of drug-induced long-QT syndrome in patients surviving to hospital admission is approximately 10.9 per million annually, though this is likely an underestimate due to pre-hospital mortality and severe underreporting to pharmacovigilance systems.
Molokhia et al. (2008) conducted an observational in Drug-induced long-QT syndrome (n=861). QT-prolonging drugs was evaluated on Incidence of drug-induced LQTS in those who survive to reach hospital (95% CI 7.8-14.8). The estimated incidence of drug-induced long-QT syndrome among patients surviving to reach the hospital in France was approximately 10.9 per million annually (95% CI 7.8-14.8).
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