Key result
Pressure-controlled intermittent coronary sinus occlusion (PiCSO) therapy is proposed for STEMI patients to potentially improve perfusion, decrease microvascular dysfunction, and reduce infarct size.
Why the study?
Conventional revascularization strategies for STEMI can still result in poor clinical outcomes due to reperfusion injury and microvascular obstruction contributing to infarct size.
Does the pressure-controlled intermittent coronary sinus occlusion (PiCSO) device improve perfusion and reduce infarct size in STEMI patients?
Does the pressure-controlled intermittent coronary sinus occlusion (PiCSO) device improve perfusion and reduce infarct size in STEMI patients?
The PiCSO device represents a potential therapeutic strategy to address reperfusion injury and microvascular obstruction in STEMI patients.
Percutaneous coronary intervention has transformed the management of ST-elevation myocardial infarction (STEMI) due to a reduction in early mortality and need for repeat revascularization. However, the conventional revascularization strategy, combined with state-of-the-art anti-thrombotic and antiplatelet therapies, can still be associated with poor clinical outcome in some patients, because of reperfusion injury and microvascular obstruction contributing to the infarct size. To address this important therapeutic need, a broad-range of device-based treatments have been introduced. This is an overview of the pressure-controlled intermittent coronary sinus occlusion (PiCSO) device (Miracor Medical SA) which has been proposed for STEMI patients. PiCSO therapy could lead to an improved perfusion, decrease microvascular dysfunction, and thus potentially reduce infarct size.
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Sehatbakhsh et al. (2023) conducted a review in ST-elevation myocardial infarction (STEMI). Pressure-controlled intermittent coronary sinus occlusion (PiCSO) was evaluated. Pressure-controlled intermittent coronary sinus occlusion (PiCSO) therapy is proposed for STEMI patients to potentially improve perfusion, decrease microvascular dysfunction, and reduce infarct size.
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