Key result
Male CD300LG rs72836561 CT-carriers had a significantly higher 24-hour ambulatory systolic blood pressure (122 mmHg vs 115 mmHg; p=0.01) compared with CC-carriers, though this was not replicated in a larger cohort using office blood pressure.
Why the study?
Does the CD300LG rs72836561 CT-carrier genotype increase blood pressure compared to CC-carriers?
Population
40 healthy males in the clinical study, and 5,886 individuals in the genetic-epidemiological study.
Comparison
CD300LG rs72836561 CT-carrier genotype vs CD300LG rs72836561 CC-carrier genotype
Design
Cross-sectional
Authors
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CT genotype linked to higher ambulatory BP in males; hypothesis-generating for genetic hypertension mechanisms, not yet practice-changing.
Cross-Sectional (n=40)
Yes
Does the CD300LG rs72836561 CT-carrier genotype increase blood pressure compared to CC-carriers?
Absolute Event Rate: 122% vs 115%
p-value: p=0.01
While a small clinical study suggested the CD300LG Arg82Cys polymorphism increases 24-hour ambulatory blood pressure, this was not replicated using office blood pressure in a large epidemiological cohort, highlighting the need for standardized measurement methods in genetic association studies.
Støy et al. (2014) conducted a cross-sectional in Healthy male carriers of CD300LG polymorphism (n=40). CD300LG rs72836561 CT-carrier status vs. CD300LG rs72836561 CC-carrier status was evaluated on 24-hour ambulatory systolic blood pressure (p=0.01). Male CD300LG rs72836561 CT-carriers had a significantly higher 24-hour ambulatory systolic blood pressure (122 mmHg vs 115 mmHg; p=0.01) compared with CC-carriers, though this was not replicated in a larger cohort using office blood pressure.
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