Key result
5-Fluorouracil provoked a pronounced decrease of O2 levels in blood and affected phosphate metabolism, whereas cisplatin had no such effects, suggesting a mechanism for 5-FU related cardiotoxicity.
Why the study?
Does 5-fluorouracil decrease the oxygen transfer capacity of erythrocytes compared to cisplatin?
Does 5-fluorouracil decrease the oxygen transfer capacity of erythrocytes compared to cisplatin?
5-fluorouracil decreases the oxygen transfer capacity of erythrocytes, providing a potential mechanistic explanation for its associated cardiotoxicity and ischemia.
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5-FU may impair erythrocyte O2 delivery; leaves open causal role in human cardiotoxicity pending clinical validation.
Spasojević et al. (2008) studied Chemotherapy related ischemia. 5-Fluorouracil and Cisplatin was evaluated on O2 level in blood and metabolism of phosphate compounds. 5-Fluorouracil provoked a pronounced decrease of O2 levels in blood and affected phosphate metabolism, whereas cisplatin had no such effects, suggesting a mechanism for 5-FU related cardiotoxicity.
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