Key result
Treatment with 5-fluorouracil in 11 patients decreased blood and plasma viscosity and was associated with reversible cardiotoxic effects in 4 patients.
Why the study?
Does 5-fluorouracil treatment cause changes in blood viscosity that explain its cardiotoxicity in patients?
Observational (n=11)
Does 5-fluorouracil treatment cause changes in blood viscosity that explain its cardiotoxicity in patients?
Treatment with 5-fluorouracil decreases blood and plasma viscosity, suggesting that hyperviscosity is unlikely to be the primary mechanism underlying 5-FU-induced cardiotoxicity.
5-FU cardiotoxicity occurs despite reduced viscosity; challenges hyperviscosity mechanism and leaves alternative pathways open for study.
Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU. The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.
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Cwikiel et al. (1995) conducted an observational in Patients treated with 5-fluorouracil (n=11). 5-fluorouracil (5-FU) was evaluated on Changes of blood and plasma viscosity, fibrinogen and hematocrit. Treatment with 5-fluorouracil in 11 patients decreased blood and plasma viscosity and was associated with reversible cardiotoxic effects in 4 patients.
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