Key result
Kidney and heart transplant patients on immunosuppressive therapy showed higher levels and loss of circadian rhythm for plasma renin activity and plasma aldosterone compared to healthy controls.
Why the study?
Does immunosuppressive therapy with cyclosporine and prednisone alter the circadian rhythm of plasma renin and aldosterone in kidney or heart transplant patients?
Observational (n=28)
Does immunosuppressive therapy with cyclosporine and prednisone alter the circadian rhythm of plasma renin and aldosterone in kidney or heart transplant patients?
Heart and kidney transplant patients on cyclosporine and prednisone exhibit hyperreninemic hyperaldosteronism and loss of normal circadian rhythms for renin and aldosterone.
The circadian rhythm (CR) of plasma renin activity (PRA), plasma aldosterone (PA), and plasma cortisol (PC) was investigated in 8 patients with kidney transplantation, and in 10 patients with heart transplantation. Ten clinically healthy subjects were studied as controls. The transplanted patients were all under cyclosporine treatment associated with prednisone (PDN). Time-qualified levels of PRA and PA were seen to be higher than normal in both groups of transplanted patients. The analysis of PRA and PA circadian rhythm provided evidence for a systematically higher level of within-day concentrations. The higher level of oscillation suggests the occurrence of a condition of hyperreninemic hyperaldosteronism. The higher levels of PRA and PA 24-h values show no periodicity. The finding suggests the abrogation of the rhythmic function for renin-aldosterone system. The disappearance of PRA-PA circadian rhythm seems to be attributable to a side effect of immunosuppressive therapy.
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Cugini et al. (1992) conducted an observational in Kidney or heart transplantation (n=28). Immunosuppressive therapy (cyclosporine and prednisone) in transplant patients vs. Clinically healthy subjects was evaluated on Circadian rhythm of plasma renin activity (PRA) and plasma aldosterone (PA). Kidney and heart transplant patients on immunosuppressive therapy showed higher levels and loss of circadian rhythm for plasma renin activity and plasma aldosterone compared to healthy controls.
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