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August 2, 2026European Journal of Organic Chemistry

Synthesis, Characterization, and Antibacterial Properties of Novel Fluorene‐Triazole Hybrids

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Authors

LSLaura G. SârbuMBM. L. BirsaSSSergiu Shova

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Overview

Randomized trial demonstrates antibacterial properties in fluorene-triazole hybrids, suggesting potential alternatives to antibiotics.

Key Points

  • This research aims to synthesize novel fluorene-triazole hybrids and evaluate their antibacterial properties.
  • Synthesis of five fluorene-based triazoles via copper(I)-catalyzed azide-alkyne cycloaddition.
  • Conversion to triazolium salts using methyl iodide and characterization through NMR, IR, UV, and mass spectrometry.
  • Testing antibacterial activity against Staphylococcus aureus and Escherichia coli, comparing minimum inhibitory concentrations with Levofloxacin.
  • All ten derivatives exhibit photoluminescent properties with large Stokes shifts of around 120 nm.
  • Triazolium salts demonstrated significant bactericidal properties against both bacterial strains tested.
  • Two triazole derivatives showed lower minimum inhibitory concentration values than the reference antibiotic Levofloxacin.

Cite This Study

Sârbu et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb101b0468a7eeab3e53https://doi.org/10.1002/ejoc.70740
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