Key result
Muscle metaboreflex activation in chronic heart failure achieves target blood pressure mainly by vasoconstriction, unlike in healthy individuals where it increases cardiac output.
This review highlights the role of skeletal muscle metaboreceptors and the hyperactive metaboreflex in contributing to sympathetic overactivation and exercise intolerance in chronic heart failure.
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May underlie exercise intolerance in HF; leaves open whether metaboreflex modulation improves outcomes.
Piepoli et al. (2013) conducted a review in Chronic heart failure (CHF). Muscle metaboreflex activation vs. Healthy individuals was evaluated. Muscle metaboreflex activation in chronic heart failure achieves target blood pressure mainly by vasoconstriction, unlike in healthy individuals where it increases cardiac output.
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