What does this research mean for the field?

In congestive heart failure, the muscle metaboreflex is attenuated while the mechanoreflex is accentuated, contributing to abnormal autonomic responses such as renal vasoconstriction. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Examine the exercise pressor reflex in health and disease, focusing on the roles of muscle afferents, metabolic sensing, and their pathological alterations in congestive heart failure.

June 21, 2005Journal of Applied Physiology

A perspective on the muscle reflex: implications for congestive heart failure

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Authors

LSLawrence I. SinowayGeneral Cardiology JLJianhua LiPennsylvania State University

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Implication

Altered reflexes may contribute to renal vasoconstriction in HF; leaves open targeted interventions.

Key Points

Examine the exercise pressor reflex in health and disease, focusing on the roles of muscle afferents, metabolic sensing, and their pathological alterations in congestive heart failure.
Synthesized physiological evidence on thin-fiber muscle afferent activation by metabolic stimuli (ATP, lactic acid) and mechanical stimuli.
Evaluated molecular mediators, including purinergic subtype 2X receptors, vanilloid receptor subtype 1, and acid-sensing ion channels.
Reviewed hemodynamic and reflex response patterns in experimental and clinical models of congestive heart failure.
Metabolic stimulation of muscle afferents is mediated by ATP and protons acting through purinergic receptors, vanilloid receptors, and acid-sensing ion channels.
Congestive heart failure alters the exercise pressor reflex by attenuating metaboreflex sensitivity while accentuating mechanoreflex responsiveness.
Accentuated muscle mechanoreflex activation directly triggers renal vasoconstriction during physical exertion in heart failure.

Cite This Study

Sinoway et al. (2005) studied this question.

synapsesocial.com/papers/6a1e874b09554abc3868e9cc https://doi.org/10.1152/japplphysiol.01405.2004

Topics

Heart failure HFrEF treatment

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A perspective on the muscle reflex: implications for congestive heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

A perspective on the muscle reflex: implications for congestive heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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