What is the clinical evidence from this study?

Study design: Other. Population: Myocardial hypertrophy. Intervention: Exercise hypertrophic preconditioning (EHP) vs. Sedentary mice. Primary outcome: Cardiac remodeling and function (myocardial hypertrophy, Nppa/Myh7 expression, LV dimensions, LVEF).

March 24, 2021CirculationOpen Access

Antihypertrophic Memory After Regression of Exercise-Induced Physiological Myocardial Hypertrophy Is Mediated by the Long Noncoding RNA Mhrt779

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Key result

Exercise hypertrophic preconditioning in mice attenuated pathological myocardial hypertrophy induced by transverse aortic constriction via the lncRNA Mhrt779 pathway.

Why the study?

It was hypothesized that antihypertrophic memory persists after regression of exercise-induced physiological myocardial hypertrophy, conferring myocardial resistance to subsequent pathological hypertrophic stress.

Does exercise hypertrophic preconditioning increase myocardial resistance to subsequent pathological hypertrophic stress in mice?

Population

C57BL/6 mice and cultured cardiomyocytes

Comparison

Exercise hypertrophic preconditioning vs sedentary controls after transverse aortic constriction or sham operation

Design

Preclinical animal and cellular experimental study

Follow-up

4 weeks

Authors

HLHairuo LinSouthern Medical University YZYingqi ZhuShanghai Veterinary Research Institute CZCankun ZhengHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Hypothesis-generating for exercise preconditioning in pressure overload; human studies needed before clinical translation.

Structured PICO

Does exercise hypertrophic preconditioning increase myocardial resistance to subsequent pathological hypertrophic stress in mice?

Population

C57BL/6 mice subjected to swimming training and subsequent transverse aortic constriction to evaluate antihypertrophic memory.

Intervention

Exercise hypertrophic preconditioning (EHP) via 21 days of swimming training followed by 1 week of regression, prior to transverse aortic constriction (TAC) or sham operation

Comparator

Sedentary mice undergoing transverse aortic constriction (TAC) or sham operation

Outcome

Cardiac remodeling and function evaluated with echocardiography, invasive left ventricular hemodynamic measurement, and histological analysis at 1 and 4 weeks after transverse aortic constrictionsurrogate

Exercise-induced physiological myocardial hypertrophy preconditioning increases resistance to subsequent pathological stress via an antihypertrophic effect mediated by the Mhrt779 pathway.

Cite This Study

Lin et al. (2021) studied Myocardial hypertrophy. Exercise hypertrophic preconditioning (EHP) vs. Sedentary mice was evaluated on Cardiac remodeling and function (myocardial hypertrophy, Nppa/Myh7 expression, LV dimensions, LVEF). Exercise hypertrophic preconditioning in mice attenuated pathological myocardial hypertrophy induced by transverse aortic constriction via the lncRNA Mhrt779 pathway.

synapsesocial.com/papers/6a6f152926770c2b8ddfd2d7 https://doi.org/10.1161/circulationaha.120.047000

Topics

Echocardiography

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Antihypertrophic Memory After Regression of Exercise-Induced Physiological Myocardial Hypertrophy Is Mediated by the Long Noncoding RNA Mhrt779

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Antihypertrophic Memory After Regression of Exercise-Induced Physiological Myocardial Hypertrophy Is Mediated by the Long Noncoding RNA Mhrt779

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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