Key result
Exercise-induced myocardial hypertrophy preconditioning reduced myocardial fibrosis and promoted fibroblast senescence via the Nrf2 signaling pathway.
Why the study?
The study aimed to investigate how exercise-induced myocardial hypertrophy preconditioning affects cardiac fibroblasts in the context of myocardial fibrosis.
Population
Male C57BL/6 mice and cultured rat myocardial fibroblasts
Comparison
Exercise preconditioning vs no exercise preconditioning
Design
Animal and in vitro preclinical study
Authors
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Hypothesis-generating for Nrf2-targeted antifibrotic strategies; does not support clinical adoption of exercise preconditioning.
Exercise-induced myocardial hypertrophy preconditioning protects against myocardial fibrosis by promoting fibroblast senescence via the Nrf2 signaling pathway.
Wei et al. (2023) studied Myocardial fibrosis. Exercise-induced myocardial hypertrophy preconditioning vs. No preconditioning was evaluated on Myocardial fibrosis and fibroblast senescence. Exercise-induced myocardial hypertrophy preconditioning reduced myocardial fibrosis and promoted fibroblast senescence via the Nrf2 signaling pathway.
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