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January 1, 2000Internal MedicineOpen Access

Depressor Effect by Exercise Training Is Associated with Amelioration of Hyperinsulinemia and Sympathetic Overactivity.

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Key result

Three weeks of exercise training significantly reduced 24-hour mean arterial pressure from 104 to 101 mmHg, which correlated with improvements in insulin sensitivity and baroreflex function.

Why the study?

Does exercise training improve blood pressure, insulin sensitivity, and sympathetic tone in hospitalized patients with essential hypertension?

Population

29 hospitalized patients with essential hypertension

Design

Cohort

Follow-up

3 weeks

Authors

KKKeisuke KohnoUniversity of TsukubaHMHidehiro MatsuokaKurume UniversityKTK TakenakaCentre Hospitalier Universitaire de Liège

Discussion

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Implication

Exercise training may aid hypertension via linked metabolic-neural effects; leaves open causal mediation in prospective trials.

Structured PICO

Does exercise training improve blood pressure, insulin sensitivity, and sympathetic tone in hospitalized patients with essential hypertension?

P
Population
29 hospitalized adults (mean age 43) with mild to moderate essential hypertension and no regular exercise habits underwent a 3-week exercise training program.
I
Intervention
Exercise training (75% max VO2, 6 min, q.i.d.) for 3 weeks
O
Outcome
Changes in 24-hour mean arterial pressure, heart rate, area under the curve of insulin (sigma insulin), and arterial baroreflex functionsurrogate

Main Result

Absolute Event Rate: 101% vs 104%

p-value: p=<0.05

Exercise training lowers blood pressure in hypertensive patients, and this depressor effect is closely associated with improvements in insulin resistance and sympathetic overactivity.

Limitations

  • Small sample size
  • Lack of a parallel control group (before-after design)
  • Short duration of the exercise training program (3 weeks)

Cite This Study

Kohno et al. (2000) studied Essential hypertension (n=29). Exercise training vs. Baseline (pre-training) was evaluated on 24-hour mean arterial pressure (p=<0.05). Three weeks of exercise training significantly reduced 24-hour mean arterial pressure from 104 to 101 mmHg, which correlated with improvements in insulin sensitivity and baroreflex function.

synapsesocial.com/papers/6a6f152a26770c2b8ddfd2dbhttps://doi.org/10.2169/internalmedicine.39.1013

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The hemodynamic link between insulin resistance and hypertension1991 · 240 citations
  2. 2Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs.1993 · 303 citations
  3. 3Plasma levels of renin, angiotensin II, and 6-ketoprostaglandin F1 alpha in endurance athletes1985 · 29 citations
  4. 4Renal Depressor Mechanisms of Physical Training in Patients With Essential Hypertension1997 · 30 citations
  5. 5Physical training and baroreceptor control of sympathetic nerve activity in humans.1994 · 189 citations