Key result
A history of preeclampsia was associated with lower flow-mediated dilatation than controls, though FMD did not correlate with GFR in either controls (r=0.19, p=0.17) or PE women (r=0.12, p=0.29).
Why the study?
Does a history of preeclampsia associate with reduced endothelial and kidney function at least 4 years postpartum compared to healthy parous controls?
Population
128 women at least 4 years postpartum, comprising 79 with a history of preeclampsia and 49 healthy parous…
Comparison
History of preeclampsia vs History of uncomplicated pregnancies
Design
Case-control
Follow-up
at least 4 years postpartum
Authors
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Supports endothelial monitoring after preeclampsia; leaves open whether dysfunction predicts renal decline prospectively.
Case-Control (n=128)
Does a history of preeclampsia associate with reduced endothelial and kidney function at least 4 years postpartum compared to healthy parous controls?
Women with a history of preeclampsia exhibit persistent endothelial dysfunction at least 4 years postpartum, but this does not correlate with decreased kidney function.
Balen et al. (2017) conducted a case-control in History of preeclampsia (n=128). History of preeclampsia vs. Healthy parous controls (uncomplicated pregnancies) was evaluated on Flow mediated dilatation (FMD), glomerular filtration rate (GFR), and albumin creatinine ratio (ACR). A history of preeclampsia was associated with lower flow-mediated dilatation than controls, though FMD did not correlate with GFR in either controls (r=0.19, p=0.17) or PE women (r=0.12, p=0.29).
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