Key result
Novel pulsatile rotary total artificial heart achieves physiologic biventricular output across simulated conditions.
Why the study?
The study was conducted to describe the properties and performance of a rotary total artificial heart that produces inherently pulsatile flow.
This benchtop characterization demonstrates that the compact ORCORAZON rotary total artificial heart can deliver tailorable, pulsatile biventricular support, paving the way for in vivo testing and potential use in smaller patients.
Advances compact total artificial heart design for smaller patients; leaves open in vivo durability and hemocompatibility testing.
This article describes the properties and performance of a rotary total artificial heart (TAH) that produces inherently pulsatile flow. The hydraulic performance of the TAH was characterized using a mock circulatory loop to simulate four physiologically relevant conditions: baseline flow, increased flow, systemic hypertension, and pulmonary hypertension. The pump has a variable shuttle rate (beats per minute), percentage dwell time, and angular velocity on either side (revolutions per minute), which allows for full control of the flow rate and pulsatility over a range of healthy and pathologic pressures and flow rates. The end-to-end length and displacement volume of the TAH are 9.8 cm and 130 mL, respectively, allowing it to fit in smaller chest cavities including those of smaller adults and juvenile humans.
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Jurney et al. (2020) studied this question. Second-generation pulsatile rotary total artificial heart (ORCORAZON) was evaluated on Hydraulic performance (pressure and flow rates) in a mock circulatory loop. The second-generation pulsatile rotary total artificial heart successfully achieved physiologic biventricular output and pressures across simulated baseline, high-flow, and hypertensive conditions.
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