Key result
Hypertensive disorders of pregnancy were associated with significantly reduced radial artery flow-mediated vasodilation compared to normal pregnancy (P<0.001).
Why the study?
Does flow-mediated vasodilation differ among normal pregnant women, preeclamptic women, and women with chronic hypertension, and does it correlate with plasma fibronectin levels?
Observational (n=95)
Does flow-mediated vasodilation differ among normal pregnant women, preeclamptic women, and women with chronic hypertension, and does it correlate with plasma fibronectin levels?
p-value: p=<0.001
Endothelial dysfunction in preeclampsia and chronic hypertension during pregnancy can be noninvasively assessed using radial artery flow-mediated vasodilation, which correlates with plasma fibronectin levels.
Supports noninvasive endothelial assessment in preeclampsia; cross-sectional data leave open prognostic value and therapeutic implications.
To clarify the vascular endothelial function in pregnant women with hypertensive disorders, we assessed the flow-mediated vasodilation in the radial artery and compared it with plasma fibronectin levels. We determined flow-mediated vasodilation by measuring the change in radial artery diameter during hyperemia in 58 normal pregnant women, 22 preeclamptic pregnant women, and 15 pregnant women with chronic hypertension. In 41 of the 95 pregnant women, we measured the plasma fibronectin levels. Flow-mediated vasodilation in preeclamptic women was significantly less than that in normal pregnant women (P:<0.001). In chronic hypertensive women, flow-mediated vasodilation was significantly less than that in normal pregnant women (P:<0.001) but more than that in preeclamptic women (P:<0.001). Flow-mediated vasodilation showed significant negative correlation with plasma fibronectin levels (P:<0.001, r=0.73). Our results indicate that the endothelial function can be noninvasively assessed in pregnant women with hypertensive disorders by measuring the flow-mediated vasodilation of the radial artery with high-resolution ultrasound.
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Yoshida et al. (2000) conducted an observational in Preeclampsia and chronic hypertension in pregnancy (n=95). Hypertensive disorders of pregnancy (preeclampsia and chronic hypertension) vs. Normal pregnant women was evaluated on Flow-mediated vasodilation in the radial artery (p=<0.001). Hypertensive disorders of pregnancy were associated with significantly reduced radial artery flow-mediated vasodilation compared to normal pregnancy (P<0.001).
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