Key result
In anesthetized normal pigs, BQ-123 at 14.4 microg/kg/min increased heart rate (99 vs 118 bpm; P<0.05) and shortened sinus node recovery time, with no effect on conduction properties.
Why the study?
Does acute systemic endothelin receptor blockade with BQ-123 alter cardiac electrophysiology in normal pigs?
Does acute systemic endothelin receptor blockade with BQ-123 alter cardiac electrophysiology in normal pigs?
In normal pigs, physiologic levels of ET-1 do not affect cardiac conduction properties, but ET-1 antagonism unmasks effects on vasomotor tone, heart rate, and sinus node automaticity.
No takes yet. Share an insight, caveat, or question.
Endogenous ET-1 does not alter conduction intervals in normal hearts; leaves open its role in diseased or arrhythmic states.
Gelzer et al. (2004) studied this question. BQ-123 vs. saline was evaluated on Cardiac electrophysiology (PR and QT interval, QRS duration, conduction times, refractory periods). In anesthetized normal pigs, BQ-123 at 14.4 microg/kg/min increased heart rate (99 vs 118 bpm; P<0.05) and shortened sinus node recovery time, with no effect on conduction properties.
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