Why the study?
Does the ETA antagonist BQ-123 reduce ventricular arrhythmias in a rat model of acute myocardial infarction?
Population
35 Wistar rats subjected to coronary artery ligation to induce acute myocardial infarction
Comparison
ET-1 receptor-A antagonist BQ-123 vs Normal saline
Design
Preclinical, randomly allocated
Follow-up
24 hours
Authors
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Does not support clinical ETA blockade post-MI; leaves open translation from rat AMI model.
Does the ETA antagonist BQ-123 reduce ventricular arrhythmias in a rat model of acute myocardial infarction?
Acute ETA blockade with BQ-123 decreases ventricular arrhythmias and arrhythmic mortality during the first 24 hours post-MI in a rat model.
Baltogiannis et al. (2005) studied this question.
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