Key result
In anaesthetized dogs, diltiazem only weakly inhibited the coronary vasoconstrictor activity and direct cardiotoxicity of endothelin-1, attenuating the flow reduction at 100 ng/kg by 60%.
Why the study?
Does diltiazem inhibit the coronary vasoconstrictor and cardiotoxic effects of intracoronary endothelin-1 in anaesthetized dogs?
Population
Anaesthetized dogs (n=10)
Comparison
Diltiazem combined with intracoronary endothelin-1 vs Intracoronary endothelin-1 alone
Design
Preclinical
Follow-up
approx 20 minutes
Authors
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Diltiazem may modulate ET-1 coronary responses in dogs; leaves open translation to human vasomotor disease.
Does diltiazem inhibit the coronary vasoconstrictor and cardiotoxic effects of intracoronary endothelin-1 in anaesthetized dogs?
Diltiazem only weakly inhibits the potent coronary vasoconstrictor activity and direct cardiotoxicity of endothelin-1 in an in vivo dog model.
Nichols et al. (1990) studied Anaesthetized dogs (n=10). Diltiazem vs. Endothelin-1 alone was evaluated on Coronary haemodynamic and cardiac functional responses to endothelin-1. In anaesthetized dogs, diltiazem only weakly inhibited the coronary vasoconstrictor activity and direct cardiotoxicity of endothelin-1, attenuating the flow reduction at 100 ng/kg by 60%.
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