Key result
Initial treatment with losartan/hydrochlorothiazide significantly increased the proportion of patients achieving goal blood pressure at 4 weeks compared to losartan monotherapy (P=0.002).
Why the study?
Does initial treatment with losartan/hydrochlorothiazide combination therapy improve achievement of goal blood pressure compared to losartan monotherapy in patients with severe hypertension?
Population
585 patients with severe hypertension
Comparison
Losartan 50 mg / hydrochlorothiazide 12.5 mg… vs Losartan monotherapy, titrated as needed at…
Design
RCT, randomized, double-blind
Follow-up
6 weeks
Authors
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Initial losartan/HCTZ achieved BP goals more often than monotherapy; leaves open whether this extends to CV outcomes in severe hypertension.
RCT (n=585)
Double-blind
randomized
Does initial treatment with losartan/hydrochlorothiazide combination therapy improve achievement of goal blood pressure compared to losartan monotherapy in patients with severe hypertension?
p-value: p=0.002
Initial combination therapy with losartan/hydrochlorothiazide is more effective and better tolerated than losartan monotherapy for achieving blood pressure goals in severe hypertension.
Salerno et al. (2004) conducted an RCT in severe hypertension (n=585). losartan/hydrochlorothiazide vs. losartan monotherapy (50-100 mg) was evaluated on achieved goal blood pressure (<90 mm Hg) at 4 weeks (p=0.002). Initial treatment with losartan/hydrochlorothiazide significantly increased the proportion of patients achieving goal blood pressure at 4 weeks compared to losartan monotherapy (P=0.002).
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