Key result
Barnidipine significantly reduced systolic blood pressure by 21.6 mmHg in patients >55 years and by 21.1 mmHg in patients ≤55 years over a 3-month period.
Why the study?
Does barnidipine effectively and safely lower blood pressure in both younger and older patients with uncomplicated hypertension?
Observational (n=20,275)
Open-label
Yes
Does barnidipine effectively and safely lower blood pressure in both younger and older patients with uncomplicated hypertension?
Barnidipine is effective and well-tolerated for lowering blood pressure in both younger and older patients with uncomplicated hypertension in a real-world setting.
Barnidipine may lower SBP similarly across ages in uncomplicated hypertension; leaves open randomized confirmation of outcomes and safety.
OBJECTIVE: The aim of this study was to compare the efficacy and tolerability of barnidipine, a strong lipophilic calcium channel blocker, in younger (≤55 for efficacy or <65 years for adverse events) versus older (>55 or ≥65 years) patients with uncomplicated hypertension. METHODS: 20,275 patients received barnidipine, 10 or 20 mg/day, as monotherapy or in combination with other antihypertensive drug(s) in the observational BArnidipine real-life Safety and tolerability In Chronic HyperTension (BASIC-HT) study. Efficacy and tolerability were assessed over a 3-month period. The present paper describes results from prespecified subgroup analyses by age not reported elsewhere. RESULTS: Both age groups showed a clinically meaningful decrease in blood pressure (BP) over time (p<0.0001). The mean systolic and diastolic BP after approximately 3 months of barnidipine therapy was well below the target value of <140/90 mmHg for individual patients, with no notable differences between age groups. The decrease in mean pulse pressure was greater in patients >55 years (-10.8 mmHg) than in patients ≤55 years (-8.7 mmHg) (p<0.0001) and the proportion of patients with pulse pressure >60 mmHg decreased from 61.1% at baseline to 24.8% at Visit 3 in patients >55 years and from 47.7% to 16.5% in patients ≤55 years (p<0.0001).The overall incidence of adverse events was low, leading to treatment discontinuation in only 3.0-3.6% of patients. Peripheral edema, a common adverse effect with calcium channel blockers in clinical practice, was reported by 2.7% of patients aged <65 years and by 4.6% of patients aged ≥65 years. CONCLUSION: The efficacy and tolerability profiles of barnidipine as monotherapy or in combination with other antihypertensive drugs were shown to be favorable in both younger and older patients in a real-life practice setting. Randomized double-blind controlled studies are needed to confirm these results.
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Lins et al. (2017) conducted an observational in Essential hypertension (n=20,275). Barnidipine vs. Baseline was evaluated on Change in systolic blood pressure from baseline to 3 months (p=<0.0001). Barnidipine significantly reduced systolic blood pressure by 21.6 mmHg in patients >55 years and by 21.1 mmHg in patients ≤55 years over a 3-month period.
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