Key result
Barnidipine 10 mg once daily significantly reduced blood pressure and isoprostane levels in patients with essential hypertension, with neutral effects on most metabolic parameters.
Why the study?
Does barnidipine 10 mg once daily improve blood pressure and serum metabolic parameters in adult patients with essential hypertension?
Does barnidipine 10 mg once daily improve blood pressure and serum metabolic parameters in adult patients with essential hypertension?
Barnidipine effectively lowers blood pressure and reduces oxidative stress (isoprostanes) in essential hypertension, without adversely affecting other metabolic, renal, or hemostatic parameters.
Barnidipine was associated with BP reduction and lower oxidative stress without metabolic effects in essential hypertension; hypothesis-generating pending randomized trials.
The effect of barnidipine, a calcium channel blocker, on metabolic parameters is not well known. The authors conducted the present pilot study to evaluate the possible effects of barnidipine on parameters involved in atherogenesis, oxidative stress, and clotting activity. This open-label intervention study included 40 adult patients with essential hypertension who received barnidipine 10 mg once daily. Barnidipine significantly reduced systolic and diastolic blood pressure as well as isoprostane levels, which represent a reliable marker of oxidative stress. In contrast, barnidipine had a neutral effect on lipid profile and apolipoprotein levels, did not influence glucose homeostasis, had no effect on renal function, and did not cause any changes in electrolyte levels. Moreover, barnidipine did not affect either the clotting/fibrinolytic status (evaluated by measurement of fibrinogen, total plasminogen activator inhibitor, tissue plasminogen activator, and a2 antiplasmin) or the enzymatic activity of the inflammatory/anti-inflammatory mediators lipoprotein-associated phospholipase A2 and paraoxonase 1, respectively. Barnidipine should be mainly considered as an antihypertensive agent with neutral effects on most of the studied metabolic parameters in hypertensive patients. Any antioxidant effect of barnidipine needs further investigation.
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Spirou et al. (2006) studied essential hypertension (n=40). Barnidipine was evaluated on Blood pressure and serum metabolic parameters. Barnidipine 10 mg once daily significantly reduced blood pressure and isoprostane levels in patients with essential hypertension, with neutral effects on most metabolic parameters.