Key result
Barnidipine exposure in patients with essential hypertension was associated with adverse events in 10.6% of patients and decreased mean blood pressure from 159.6/92.5 to 138.2/81.7 mmHg.
Why the study?
Does barnidipine demonstrate good tolerability and efficacy in a real-life population of patients with essential hypertension?
Observational (n=20,479)
Does barnidipine demonstrate good tolerability and efficacy in a real-life population of patients with essential hypertension?
In a large real-world observational study, barnidipine was well-tolerated and effectively lowered blood pressure in patients with essential hypertension.
Supports barnidipine consideration in real-world hypertension; leaves open need for randomized confirmation before practice change.
INTRODUCTION: Blood pressure (BP) is generally poorly controlled in hypertensive patients. One cause is poor adherence to drugs, which can be improved by treatments combining good efficacy and tolerability. Barnidipine is a strong lipophilic calcium channel blocker (CCB) with efficacy similar to other dihydropyridines. OBJECTIVE: BASIC HT is an observational study in a large population of patients with essential hypertension to evaluate the tolerability of barnidipine in a real-life setting. METHODS: 20479 patients were enrolled in the study. Tolerability and efficacy was assessed at 2 visits during a 3-month period. 20275 patients were included in the analysis. RESULTS: Adverse events were reported by 10.6% of the patients, leading to treatment discontinuation in 3%. Events were those expected with CCBs. The drop-out rate was 8%. Mean systolic and diastolic pressure decreased from 159.6 to 138.2 and from 92.5 to 81.7 mmHg. CONCLUSION: The decrease in BP, is probably due to stimulation of good adherence by barnidipine.
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Lins et al. (2015) conducted an observational in essential hypertension (n=20,479). Barnidipine was evaluated on Tolerability (adverse events). Barnidipine exposure in patients with essential hypertension was associated with adverse events in 10.6% of patients and decreased mean blood pressure from 159.6/92.5 to 138.2/81.7 mmHg.
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