Key result
Amlodipine titration to 10 mg linked to ~13-mmHg systolic blood pressure reduction in Asian patients.
Why the study?
Does titration of amlodipine from 5 mg to 10 mg similarly improve blood pressure in Asian compared to Western patients with mild-to-moderate hypertension?
Observational (n=543)
Open-label
Yes
Does titration of amlodipine from 5 mg to 10 mg similarly improve blood pressure in Asian compared to Western patients with mild-to-moderate hypertension?
Titrating amlodipine from 5 mg to 10 mg provides significant and comparable blood pressure reductions in both Asian and Western patients with mild-to-moderate hypertension.
Answers are grounded in this paper and cite their sources.
May support amlodipine titration in Asian hypertension; extends Western data but leaves open need for RCTs.
In this retrospective analysis, data pooled from two Phase III/IV open-label Asian studies were used to quantify the additional blood pressure efficacy achieved when titrating amlodipine from 5 mg to 10 mg in mild/moderate hypertensive patients, and compared to data pooled from three Western studies. The primary efficacy end point was the change from baseline in sitting systolic blood pressure (SBP) and diastolic blood pressure (DBP) to the specified time point (4-8 weeks, depending on the trial). For the Asian analysis (n=174), both mean SBP and DBP were significantly decreased at the final visit (SBP -13.3 mmHg, 95% confidence interval [CI] -15.5 to -11.0; DBP -9.2 mmHg, 95% CI -10.6 to -7.8; both P<0.0001). These results were similar to the Western analysis (n=369; SBP -11.5 mmHg, 95% CI -13.1 to -10.0; DBP -6.3, 95% CI -7.1 to -5.5; both P<0.0001). In summary, titration of amlodipine from 5 mg to 10 mg significantly decreased both SBP and DBP in Asian patients with mild-to-moderate hypertension.
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Kario et al. (2013) conducted an observational in Mild or moderate hypertension (n=543). Amlodipine vs. Baseline (on 5 mg daily) was evaluated on Change from baseline to final visit in sitting systolic blood pressure (SBP) in the Asian cohort (MD -13.3 mmHg, 95% CI -15.5 to -11.0, p=<0.0001).
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