Key result
Lower flow-mediated dilation (<2.0) was independently associated with a higher prevalence of left main coronary artery disease (OR 3.89) and a smaller minimal lumen area in the culprit lesion.
Why the study?
Is impaired flow-mediated dilation associated with greater severity and vulnerability of culprit plaque in patients with coronary artery disease?
Observational (n=245)
Blinded assessor
No
Is impaired flow-mediated dilation associated with greater severity and vulnerability of culprit plaque in patients with coronary artery disease?
Flow-mediated dilation may serve as a useful noninvasive indicator for identifying patients with severe coronary artery disease, as lower FMD correlates with higher incidence of left main disease and smaller minimal lumen area.
Impaired FMD may identify higher-risk CAD; hypothesis-generating and should not yet change practice.
; P = 0.035). The prevalence ofvulnerable plaque characteristics was comparable between the 2 groups.Patients with lower FMD had a higher incidence of LM disease and a smaller MLA in the culprit lesion. FMD may be a useful, noninvasive indicator for identifying patients with severe coronary artery disease.
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Nemoto et al. (2019) conducted an observational in Coronary Artery Disease (Stable Angina) (n=245). Lower flow-mediated dilation (FMD < 2.0) vs. Higher flow-mediated dilation (FMD ≥ 2.0) was evaluated on Prevalence of left main (LM) disease (OR 3.89, 95% CI 1.12-15.5, p=0.033). Lower flow-mediated dilation (<2.0) was independently associated with a higher prevalence of left main coronary artery disease (OR 3.89) and a smaller minimal lumen area in the culprit lesion.
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