Flow-Mediated Vasodilation was Found to be an Independent Predictor of Changes in the Carotid Plaque Status During a 5-Year Follow-Up
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Key result
Flow-mediated vasodilation independently predicted changes in carotid plaque status over a 5-year follow-up, with a 1 SD increase in FMD associated with a lower risk of plaque progression (OR 0.81).
Population
760 community-dwelling adults aged 70 years from Uppsala, Sweden, with valid measurements of carotid…
Design
Cohort, Image readers were blinded to previous plaque status.
Follow-up
5 years
Authors
Discussion
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Implication
May support FMD monitoring for plaque risk in elderly patients; leaves open its incremental value over conventional markers.
Study Design
Type
Cohort (n=1,016)
Blinding
Blinded outcome assessment
Multicenter
No
Structured PICO
P
Population
1,016 community-dwelling adults aged 70 years from Sweden, followed for 5 years to evaluate flow-mediated vasodilation as a predictor of carotid plaque progression.
E
Exposure
Measurement of flow-mediated dilatation (FMD) in the brachial artery and endothelium-dependent vasodilation (EDV) using invasive forearm technique with acetylcholine.
O
Outcome
Change in carotid intima-media thickness (IMT) and change in carotid plaque burden (number of carotid arteries with plaques: 0, 1, or 2) over 5 years.surrogate
Main Result
Odds Ratio: 0.81 (95% CI 0.68–0.95)
p-value: p=0.010
Flow-mediated vasodilation (FMD) is an independent predictor of carotid plaque progression over 5 years in elderly subjects, suggesting its utility as a marker for atherosclerotic risk.
Limitations
- Findings are limited to Caucasians 70 years of age, limiting generalizability to other ethnic and age groups.
- The study had a moderate participation rate (50.1%).
- Plaque progression cannot be properly evaluated in subjects with bilateral plaques at both baseline and follow-up examinations.
- Limited to Caucasians 70 years of age
- Moderate participation rate (50.1%)
- Plaque progression cannot be properly evaluated in subjects with bilateral plaques at both examinations
Cite This Study
Lars Lind (2013) conducted a cohort in Atherosclerosis (n=1,016). Flow-mediated vasodilation (FMD) was evaluated on Change in carotid plaque burden (OR 0.81, 95% CI 0.68-0.95, p=0.010). Flow-mediated vasodilation independently predicted changes in carotid plaque status over a 5-year follow-up, with a 1 SD increase in FMD associated with a lower risk of plaque progression (OR 0.81).
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