Key result
Tracing a demarcated ring of cells in 8 human embryos demonstrated that the inlet component of the morphologically right ventricle is derived from the ascending limb of the embryonic ventricular loop.
Population
8 human embryos, encompassing stages 14-23 of the Carnegie classification.
Design
Preclinical
Authors
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May inform congenital RV anomaly etiology; leaves open clinical translation from embryonic tracing data.
This embryological study demonstrates that the inlet of the right ventricle originates from the ascending limb of the ventricular loop, providing insights into normal and abnormal cardiac septation.
Lamers et al. (1992) studied Ventricular septation in the human heart (n=8). Monoclonal antibody against an antigen to neural tissue from the chick was evaluated on Fate of the ring of cells separating the descending and ascending limbs of the developing ventricular loop. Tracing a demarcated ring of cells in 8 human embryos demonstrated that the inlet component of the morphologically right ventricle is derived from the ascending limb of the embryonic ventricular loop.
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