Key result
The muscular interventricular septum forms from fusing ventricular trabeculations growing away from the atria.
This preclinical study demonstrates that the muscular region of the interventricular septum originates from the fusion of ventricular trabeculations, providing insight into normal cardiac septation.
Does not guide clinical management of septal defects; hypothesis-generating for human cardiac septation mechanisms.
The structures that participate in normal ventricular septation, and to what extent they do so, are questions not yet clarified. Even less is known about how much each of the embryonic structures contributes to the topography of the mature interventricular septum (IVS). The aim of the present paper is to investigate the significance of ventricular trabeculations in the normal development of the muscular region (the middle and apical thirds) of the IVS and to determine the direction in which it grows during cardiac septation. Anatomical studies and in vivo labelling were carried out in chicken embryo hearts at stage 18HH, tracing the labels up to stage 36HH. We analysed the results by measuring the distance between the labelled structures at the beginning and end of the experiments. We demonstrate that the muscular region of the septum originates by the fusion of the ventricular trabeculations with evidence that during cardiac development, the IVS as well as the ventricular cavities grow in opposite direction to the atria.
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Contreras‐Ramos et al. (2008) studied Normal development of the interventricular septum. In vivo labelling was evaluated on Distance between the labelled structures at the beginning and end of the experiments. The muscular region of the interventricular septum originates by the fusion of the ventricular trabeculations, growing in the opposite direction to the atria during cardiac development.
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