Key result
Muscular ventricular septum forms from trabecular aggregation and shares a single developmental origin.
Why the study?
The developmental origin and morphogenesis of the muscular ventricular septum in the chick embryo heart were not fully understood.
Population
Chick embryo hearts from stages 22 to 33 of Hamburger & Hamilton (1951)
Comparison
Myocardium with microfiber markers vs adjacent myocardium without markers
Design
Experimental study using microfiber markers and radioautography
Follow-up
Up to 7 days
Authors
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Chick embryo data warrant no clinical change in congenital heart disease; leaves open conservation of trabecular aggregation in mammalian septation.
This experimental study demonstrates that the muscular ventricular septum in chick embryos is formed by the aggregation and coaptation of trabeculae, indicating a single developmental origin.
Harh et al. (1975) studied Cardiac morphogenesis. Microfiber markers and radioautography was evaluated on Morphogenesis of the ventricular septum. Microfiber markers and radioautography in chick embryos demonstrated that the muscular ventricular septum is formed by aggregation and coaptation of trabeculae and is of a single developmental origin.
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