Key result
In two-kidney, one-clip hypertensive rats, the ANG II-induced intracellular Ca2+ response in afferent arterioles was reduced by COX-1-derived prostaglandins compared to control animals.
Population
Freshly isolated afferent arterioles (AA) from two-kidney, one-clip hypertensive (2K1C) rats and control rats
Comparison
Angiotensin II stimulation vs Control rats, sham rats, and comparison between…
Design
Preclinical
Authors
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Should not yet influence COX inhibitor use in hypertension; extends animal evidence on prostaglandin modulation of ANG II responses.
In 2K1C hypertensive rats, the ANG II-induced intracellular calcium response in afferent arterioles is reduced by COX-1-derived prostaglandins, unlike in control animals.
Helle et al. (2006) studied Two-kidney, one-clip hypertension. Angiotensin II stimulation and COX-1 inhibition vs. Control/sham rats was evaluated on Intracellular Ca2+ response in the afferent arteriole. In two-kidney, one-clip hypertensive rats, the ANG II-induced intracellular Ca2+ response in afferent arterioles was reduced by COX-1-derived prostaglandins compared to control animals.
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