Why the study?
Does the use of DMARDs and COX-2 inhibitors alter the risk of hospitalization for congestive heart failure in patients with rheumatoid arthritis?
Does the use of DMARDs and COX-2 inhibitors alter the risk of hospitalization for congestive heart failure in patients with rheumatoid arthritis?
In patients with rheumatoid arthritis, DMARD use is associated with a lower risk of incident heart failure hospitalization, whereas COX-2 inhibitors exhibit drug-specific effects on heart failure risk.
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DMARD use was associated with lower CHF hospitalization risk in RA; leaves open whether this reflects confounding or warrants prospective trials before practice change.
Bernatsky et al. (2005) studied this question.
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