Why the study?
Does chronic therapy with cicaprost, fosinopril, or their combination reduce the progression of diabetic nephropathy in uninephrectomized streptozotocin-induced diabetic rats?
Population
Uninephrectomized streptozotocin-induced diabetic rats maintained with plasma glucose between 13.7 and 22.0…
Comparison
Chronic therapy with cicaprost, fosinopril, or… vs Control rats (untreated diabetic rats)
Design
Preclinical
Follow-up
8 months
Authors
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Hypothesis-generating in diabetic rat model; leaves open translation of cicaprost to human nephropathy trials.
Does chronic therapy with cicaprost, fosinopril, or their combination reduce the progression of diabetic nephropathy in uninephrectomized streptozotocin-induced diabetic rats?
Cicaprost and fosinopril equivalently attenuate the progression of diabetic nephropathy in a rat model, though cicaprost's nephroprotection appears independent of systemic blood pressure reduction.
Eduardo Villa (1997) studied this question.
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