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October 1, 2000EP EuropaceOpen Access

Efficacy and tolerability of continuous overdrive atrial pacing in atrial fibrillation

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Why the study?

Does consistent atrial overdrive pacing reduce premature atrial complexes and automatic mode switching in patients with sick sinus syndrome?

Population

15 patients with sick sinus syndrome implanted with a Thera DR pacemaker (model 7940 or 7960, Medtronic Inc.)

Comparison

Rate adaptive dual chamber pacing + consistent… vs Rate adaptive dual chamber pacing for an 8-week…

Design

RCT, randomly programmed

Follow-up

8 weeks per pacing mode

Authors

CLCharlene LamPennsylvania State University

Discussion

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Overview

Consistent atrial pacing reduces premature atrial complexes without lowering mode switching episodes; challenges ectopy suppression as a strategy to reduce atrial tachyarrhythmia burden.

Structured PICO

Does consistent atrial overdrive pacing reduce premature atrial complexes and automatic mode switching in patients with sick sinus syndrome?

P
Population
15 patients with sick sinus syndrome implanted with a Thera DR pacemaker (model 7940 or 7960, Medtronic Inc.)
I
Intervention
Rate adaptive dual chamber pacing (DDDR) + consistent atrial pacing mode (automatically paced the atrium at 30 ms shorter than the sinus P-P interval) for an 8-week study period
C
Comparator
Rate adaptive dual chamber pacing (DDDR) for an 8-week study period
O
Outcome
Number of automatic mode switching episodes and number of premature atrial complexessurrogate

Consistent atrial overdrive pacing significantly reduces premature atrial complexes without increasing overall atrial rate, but does not significantly reduce automatic mode switching episodes.

Cite This Study

Charlene Lam (2000) studied this question.

synapsesocial.com/papers/6a6f26eaf44fa9f079dc8f03https://doi.org/10.1053/eupc.2000.0124
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DDD Pacing: An Effective Treatment Modality for Recurrent Atrial Arrhythmias1988 · 108 citations
  2. 2Prevention of Intra‐Atrial Reentry by Chronic Atrial Pacing1980 · 14 citations
  3. 3Permanent Left Atrial Pacing with a Specifically Designed Coronary Sinus Lead1997 · 44 citations
  4. 4Quality of Life and Clinical Outcomes in Elderly Patients Treated with Ventricular Pacing as Compared with Dual-Chamber Pacing1999 · 37 citations
  5. 5Atrial Pacing Periablation for Prevention of Paroxysmal Atrial Fibrillation1999 · 172 citations