January 1, 2001Journal of Hypertension

Quinapril treatment enhances vascular sensitivity to insulin

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Why the study?

Does quinapril improve vascular sensitivity to insulin in hypertensive subjects on a sodium-restricted diet?

Structured PICO

Does quinapril improve vascular sensitivity to insulin in hypertensive subjects on a sodium-restricted diet?

Population

11 hypertensive subjects maintained on a 75 mmol/day sodium diet for 3 days prior to each study

Intervention

Quinapril therapy for 3 months

Comparator

Placebo

Outcome

Vascular sensitivity to insulin (assessed by determination of the insulin ED50 from dorsal hand vein linear variable differential transformer in phenylephrine-preconstricted vessels)surrogate

Quinapril therapy for 3 months improves vascular sensitivity to insulin and isoproterenol-mediated relaxation in hypertensive patients on a sodium-restricted diet.

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Implication

Quinapril enhances vascular insulin sensitivity in salt-restricted hypertensives; extends ACE inhibitor benefits to metabolic vascular function.

Cite This Study

Feldman et al. (2001) studied this question.

synapsesocial.com/papers/6a6f283531a3df8243279644 https://doi.org/10.1097/00004872-200101000-00015

Topics

Hypertension management

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Implication

Quinapril enhances vascular insulin sensitivity in salt-restricted hypertensives; extends ACE inhibitor benefits to metabolic vascular function.

Quinapril treatment enhances vascular sensitivity to insulin

Structured PICO

Discussion

Implication

Cite This Study

Topics

Quinapril treatment enhances vascular sensitivity to insulin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider