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March 1, 1998The Journals of Gerontology Series AOpen Access

The Effect of Adenosine on the Reduced Heart Rate Response to Exercise in the Elderly

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Why the study?

Does theophylline improve the maximum heart rate response to exercise in older healthy men compared to placebo?

Population

24 healthy men, comprising 12 young and 12 older individuals.

Comparison

Theophylline administered to achieve plasma… vs Placebo during maximum exercise tests.

Design

Other

Authors

EAE. AndrosUniversity of Colorado HealthJGJ G GerberLeibniz University Hannover

Discussion

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Overview

Does not support theophylline for age-related chronotropic incompetence; leaves open intrinsic cardiac mechanisms and requires prospective confirmation.

Structured PICO

Does theophylline improve the maximum heart rate response to exercise in older healthy men compared to placebo?

P
Population
24 healthy men, comprising 12 young (mean age 27.3 +/- .61 years) and 12 older (mean age 66.8 +/- .9 years) individuals.
I
Intervention
Theophylline administered to achieve plasma concentrations between 15-20 micrograms/ml during maximum exercise tests.
C
Comparator
Placebo during maximum exercise tests.
O
Outcome
Maximum heart rate to exercise.surrogate

Theophylline administration did not significantly reverse the diminished maximal exercise heart rate associated with aging, suggesting the mechanism is intrinsic to cardiac excitatory tissue rather than due to excessive adenosine.

Cite This Study

Andros et al. (1998) studied this question.

synapsesocial.com/papers/6a6f293ffebe604dd7082b5ahttps://doi.org/10.1093/gerona/53a.2.m87
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Adenosine in Promoting Cardiac -Adrenergic Subsensitivity in Aging Humans1995 · 9 citations
  2. 2Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males1985 · 208 citations
  3. 3The effect of age on heart rate in subjects free of heart disease. Studies by ambulatory electrocardiography and maximal exercise stress test.1982 · 177 citations
  4. 4Normal cardiopulmonary responses during incremental exercise in 20??? to 70-yr-old men1994 · 225 citations
  5. 5Age Differences in Plasma Norepinephrine Kinetics in Humans1986 · 125 citations