Why the study?
Does beta adrenoceptor-mediated responsiveness to isoproterenol differ between young and old subjects?
Does beta adrenoceptor-mediated responsiveness to isoproterenol differ between young and old subjects?
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Elderly subjects exhibit decreased beta adrenoceptor-mediated responsiveness to isoproterenol compared to young subjects, suggesting a generalized decrease in beta adrenoceptor function with age.
Beta adrenoceptor-mediated responsiveness to isoproterenol was compared in young and old subjects using the production of cyclic adenosine monophosphate (cyclic AMP) by lymphocytes as an index. The mean log dose-response curve for the elderly group was displaced to the right and the mean maximum response was less than that for the young subjects. The results corroborate evidence of a decreased response to isoproterenol-induced increases in heart rate in the elderly and raise the possibility of a generalized decrease in beta adrenoceptor-mediated functions in old age.
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Dillon et al. (1980) studied this question.
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