Why the study?
Does beta adrenoceptor-mediated responsiveness to isoproterenol differ between young and old subjects?
Population
Young and old subjects
Comparison
Isoproterenol vs Young subjects (compared to old subjects)
Design
Cross-sectional
Authors
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Suggests cautious beta-agonist dosing in elderly; leaves open effects on beta-blocker use and requires prospective confirmation.
Does beta adrenoceptor-mediated responsiveness to isoproterenol differ between young and old subjects?
Elderly subjects exhibit decreased beta adrenoceptor-mediated responsiveness to isoproterenol compared to young subjects, suggesting a generalized decrease in beta adrenoceptor function with age.
Dillon et al. (1980) studied this question.
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