Why the study?
Does aging decrease the magnitude of heart rate increase after intravascular injection of epinephrine in elective surgical patients?
Population
30 elective surgical patients between 21 and 81 years old
Comparison
Intravascular injection of 3 mL lidocaine with… vs Intravascular injection of 3 mL lidocaine plain
Design
RCT, randomized, double-blind
Authors
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Epinephrine test doses may be less reliable for detecting intravascular injection in older patients; challenges assumptions of uniform chronotropic response across ages.
Does aging decrease the magnitude of heart rate increase after intravascular injection of epinephrine in elective surgical patients?
Aging significantly reduces the heart rate response to a 10 microgram epinephrine test dose, suggesting that standard test doses may be unreliable for detecting intravascular injection in older patients.
Guinard et al. (1995) studied this question.
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