Key result
Cardiac oxidative stress plays a crucial role in the pathogenesis of diastolic dysfunction, suggesting that targeted antioxidant therapies may offer new diagnostic and therapeutic avenues.
Design
Review
Authors
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May support antioxidant exploration in HFpEF; leaves open efficacy pending prospective trials.
Oxidative stress and resulting modifications to cardiac proteins represent a distinct pathophysiological mechanism and potential therapeutic target for HFpEF, which has not responded well to traditional HFrEF therapies.
Jeong et al. (2015) conducted a review in Diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF). Cardiac oxidative stress plays a crucial role in the pathogenesis of diastolic dysfunction, suggesting that targeted antioxidant therapies may offer new diagnostic and therapeutic avenues.
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