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September 15, 2010LipidsOpen Access

Dietary t10,c12‐CLA but not c9,t11 CLA Reduces Adipocyte Size in the Absence of Changes in the Adipose Renin–Angiotensin System in fa/fa Zucker Rats

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Why the study?

Does cis(c)9,trans(t)11-CLA or t10,c12-CLA diet reduce adipocyte size and alter adipokines in male fa/fa Zucker rats?

Population

Male fa/fa Zucker rats

Comparison

cis9,trans11-CLA or t10,c12-CLA diet for 8 weeks vs control diet

Design

Preclinical

Follow-up

8 weeks

Authors

VDVanessa DeClercqPZPeter ZahradkaCTCarla G. Taylor

Discussion

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Overview

t10,c12-CLA may reduce adipocyte size independently of adipose RAS in obese rats; leaves open human translation.

Structured PICO

Does cis(c)9,trans(t)11-CLA or t10,c12-CLA diet reduce adipocyte size and alter adipokines in male fa/fa Zucker rats?

P
Population
Male fa/fa Zucker rats
I
Intervention
cis(c)9,trans(t)11-CLA or t10,c12-CLA diet for 8 weeks
C
Comparator
control diet
O
Outcome
adipocyte size and adipokines associated with the local adipose renin-angiotensin systemsurrogate

Dietary t10,c12-CLA reduces adipocyte size in obese rats without affecting the local adipose renin-angiotensin system.

Cite This Study

DeClercq et al. (2010) studied this question.

synapsesocial.com/papers/6a6f2ff5660549caf2c3bf53https://doi.org/10.1007/s11745-010-3469-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension2004 · 340 citations
  2. 2Attenuation of Diet-Induced Weight Gain and Adiposity through Increased Energy Expenditure in Mice Lacking Angiotensin II Type 1a Receptor2005 · 168 citations
  3. 3The usefulness of circulating adipokine levels for the assessment of obesity-related health problems2008 · 109 citations
  4. 4Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems?2009 · 100 citations
  5. 5Adipose Tissue, Inflammation, and Cardiovascular Disease2005 · 2,128 citations