Why the study?
Does mycophenolate mofetil prevent salt-sensitive hypertension following protein overload in rats?
Population
Female Lewis rats
Comparison
Mycophenolate mofetil administered during 2… vs Protein overload followed by high-salt diet…
Design
Preclinical
Follow-up
8 weeks (2 weeks protein overload + 6 weeks high-salt diet)
Authors
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May implicate renal inflammation in salt-sensitive hypertension after proteinuria; extends mechanistic data but leaves open human translation.
Does mycophenolate mofetil prevent salt-sensitive hypertension following protein overload in rats?
Proteinuria induces renal inflammatory infiltrate which contributes to the pathogenesis of salt-sensitive hypertension, providing a direct link between proteinuria and hypertension.
Alvarez et al. (2002) studied this question.
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