Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1985Blood & VesselOpen Access

Heparin and platelet release reaction in diabetes mellitus.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does intravenous heparin injection induce different levels of platelet factor 4 release in diabetic patients depending on retinopathy and glycemic control compared to normal subjects?

Population

6 normal subjects and 50 patients with diabetes mellitus, divided by presence of diabetic retinopathy and…

Comparison

Intravenous injection of heparin (5,000 units). vs Normal subjects and comparisons among diabetic…

Design

Cohort

Follow-up

60 minutes

Authors

YOYasuo OhkiKNKazukiyo NakaoEdogawa HospitalCSChikako ShimanoHyogo Prefectural Awaji Medical Center

Discussion

Loading...

Member takes

Implication

May link poor glycemic control to heightened platelet activation in diabetes; hypothesis-generating for microvascular risk and needs prospective validation.

Structured PICO

Does intravenous heparin injection induce different levels of platelet factor 4 release in diabetic patients depending on retinopathy and glycemic control compared to normal subjects?

P
Population
6 normal subjects (aged 27-52 years) and 50 patients with diabetes mellitus (aged 23-80 years), divided by presence of diabetic retinopathy (30 without, 20 with) and glycemic control status.
I
Intervention
Intravenous injection of heparin (5,000 units).
C
Comparator
Normal subjects and comparisons among diabetic subgroups (with/without retinopathy, good/poor control).
O
Outcome
Plasma level of platelet factor 4 (PF-4) before and 15, 30, and 60 minutes after heparin injection.surrogate

Heparin-induced platelet factor 4 release is elevated in poorly controlled diabetics and those with retinopathy, suggesting increased platelet activation that may contribute to microvascular complications.

Limitations

  • Inability to distinguish between platelet-derived PF-4 and the heparin-mobilizable pool of PF-4 from the endothelial surface without further investigation.

Cite This Study

Ohki et al. (1985) studied this question.

synapsesocial.com/papers/6a6f39fa2163a0a01bc38db3https://doi.org/10.2491/jjsth1970.16.514
View Full Paper
Ask AI
Bookmark
Share