Platelet Parameters in Diabetes Mellitus in Relation to HbA1c Levels

Background Immature platelet fraction IPF is a new hematologic parameter that reflects the rate of thrombopoiesis. It has been suggested as a predictor of platelet recovery in patients with thrombocytopenia as well as an indicator of platelet activity. IPF is elevated in patients with diabetes and has been associated with poor glycaemic control and an increased risk of cardiovascular complications. This study aimed to investigate the relationship between IPF and platelet count in patients with diabetes mellitus and thrombocytopenia.Methods This descriptive cross-sectional study was conducted to evaluate patients diabetic status with platelet indices documented focusing specifically on the immature platelet fraction.Results The results of this study which was conducted involving 60 patients 25 males 35 females revealed a trend of increasing platelet parameters with rising HbA1c levels. Patients with HbA1c lt6 had a mean platelet count of 2.83 platelet distribution width PDW of 14.35 plateletcrit PCT of 0.24 mean platelet volume MPV of 8.72 and IPF of 4.34. For HbA1c levels between 6-8 values increased to 2.96 platelet count 15.92 PDW 0.28 PCT 9.98 MPV and 3.99 IPF. Patients with HbA1c gt8 showed the highest values with 3.25 platelet count 15.94 PDW 0.31 PCT 10.08 MPV and 4.77 IPF indicating a positive correlation between glycaemic levels and platelet activity.Conclusion This study revealed no significant differences in platelet parameters according to glycaemic control although the mean IPF value was elevated above the normal range while the mean MPV remained within the normal range. nbsp