Key result
In patients with diabetes, an immature platelet fraction above the median was associated with a lower prevalence of coronary artery disease (OR 0.57; 95% CI 0.36-0.91; P=0.02).
Why the study?
Diabetes mellitus is associated with a prothrombotic state and altered platelet function, but the impact of diabetes and glucose control on immature platelet fraction and its relationship with coronary artery disease needed evaluation.
Does diabetes mellitus impact immature platelet fraction levels and is it associated with the prevalence and extent of coronary artery disease?
Population
1781 consecutive patients undergoing coronary angiography
Comparison
Patients with diabetes mellitus vs without diabetes mellitus
Design
Cross-sectional study
Authors
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IPF unrelated to diabetes or glycemic control and linked to modestly lower CAD prevalence in DM; leaves open any prognostic role pending prospective data.
Observational (n=1,781)
Does diabetes mellitus impact immature platelet fraction levels and is it associated with the prevalence and extent of coronary artery disease?
Odds Ratio: 0.57 (95% CI 0.36–0.91)
Absolute Event Rate: 80.5% vs 86.5%
p-value: p=0.02
Diabetes mellitus does not independently predict elevated immature platelet fraction, and elevated IPF is not a reliable cardiovascular risk marker for CAD extent in diabetic patients.
Verdoia et al. (2020) conducted an observational in Coronary artery disease (n=1,781). Immature platelet fraction greater than the median vs. Immature platelet fraction less than or equal to the median was evaluated on Prevalence of coronary artery disease (OR 0.57, 95% CI 0.36-0.91, p=0.02). In patients with diabetes, an immature platelet fraction above the median was associated with a lower prevalence of coronary artery disease (OR 0.57; 95% CI 0.36-0.91; P=0.02).
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